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Ki-67 Labeling Index in Primary Invasive Breast Cancer from Sudanese Patients : A Pilot Study
Joint Authors
Barberis, Massimo Costanzo
Osman, Ihsan
Mariani-Costantini, Renato
Awadelkarim, Khalid Dafaallah
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Ki-67 labeling index has been linked to patient outcome in breast cancer patients.
However, very few published reports have examined Ki-67 labeling index in African breast cancer patients.
Sixty-two Sudanese breast cancer patients with primary invasive tumors were immunostained for Ki-67, ER, PR, Her-2/neu, CK5/6, and CK17.
Ki-67 labeling index ranged from 0% to 50%, with a median of 5% (interquartile range 0–10).
Low Ki-67 labeling index (immunostaining < 10%) was detected in 43/62 (69.4%) with a median of 0 (interquartile range 0–5), whereas high Ki-67 labeling index (immunostaining ≥ 10%) was revealed in 19/62 (30.6%) with a median of 20 (interquartile range 12–26).
Ki-67 labeling index was significantly associated with tumor grade (P=0.022, Mann-Whitney U Test).
There were no significant group differences between Ki-67 labeling index and ER (P=0.43), PR (P=0.7), Her-2/neu (P=0.45), CK5/6 (P=0.29), CK17 (P=0.55), pathologic stage (P=0.4), tumor histology (P=0.99), breast cancer subtypes (P=0.47), tumor size (P=0.16), and age at diagnosis (P=0.6).
These results suggested that Ki-67 labeling index correlates with tumor differentiation and not with the tumor size or any other tested marker in Sudanese breast cancers.
Thus, Ki-67 labeling index could be considered as a reliable measure of tumor proliferative fraction in Sudan.
American Psychological Association (APA)
Awadelkarim, Khalid Dafaallah& Mariani-Costantini, Renato& Osman, Ihsan& Barberis, Massimo Costanzo. 2012. Ki-67 Labeling Index in Primary Invasive Breast Cancer from Sudanese Patients : A Pilot Study. ISRN Pathology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-455873
Modern Language Association (MLA)
Awadelkarim, Khalid Dafaallah…[et al.]. Ki-67 Labeling Index in Primary Invasive Breast Cancer from Sudanese Patients : A Pilot Study. ISRN Pathology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-455873
American Medical Association (AMA)
Awadelkarim, Khalid Dafaallah& Mariani-Costantini, Renato& Osman, Ihsan& Barberis, Massimo Costanzo. Ki-67 Labeling Index in Primary Invasive Breast Cancer from Sudanese Patients : A Pilot Study. ISRN Pathology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-455873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455873