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Predictive Biomarkers of Bacillus Calmette-Guérin Immunotherapy Response in Bladder Cancer : Where Are We Now?
Joint Authors
Lima, Luís
Longatto-Filho, Adhemar
Santos, Lúcio
Dinis-Ribeiro, Mário
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-07
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The most effective therapeutic option for managing nonmuscle invasive bladder cancer (NMIBC), over the last 30 years, consists of intravesical instillations with the attenuated strain Bacillus Calmette-Guérin (the BCG vaccine).
This has been performed as an adjuvant therapeutic to transurethral resection of bladder tumour (TURBT) and mostly directed towards patients with high-grade tumours, T1 tumours, and in situ carcinomas.
However, from 20% to 40% of the patients do not respond and frequently present tumour progression.
Since BCG effectiveness is unpredictable, it is important to find consistent biomarkers that can aid either in the prediction of the outcome and/or side effects development.
Accordingly, we conducted a systematic critical review to identify the most preeminent predictive molecular markers associated with BCG response.
To the best of our knowledge, this is the first review exclusively focusing on predictive biomarkers for BCG treatment outcome.
Using a specific query, 1324 abstracts were gathered, then inclusion/exclusion criteria were applied, and finally 87 manuscripts were included.
Several molecules, including CD68 and genetic polymorphisms, have been identified as promising surrogate biomarkers.
Combinatory analysis of the candidate predictive markers is a crucial step to create a predictive profile of treatment response.
American Psychological Association (APA)
Lima, Luís& Dinis-Ribeiro, Mário& Longatto-Filho, Adhemar& Santos, Lúcio. 2012. Predictive Biomarkers of Bacillus Calmette-Guérin Immunotherapy Response in Bladder Cancer : Where Are We Now?. Advances in Urology،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-455907
Modern Language Association (MLA)
Lima, Luís…[et al.]. Predictive Biomarkers of Bacillus Calmette-Guérin Immunotherapy Response in Bladder Cancer : Where Are We Now?. Advances in Urology No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-455907
American Medical Association (AMA)
Lima, Luís& Dinis-Ribeiro, Mário& Longatto-Filho, Adhemar& Santos, Lúcio. Predictive Biomarkers of Bacillus Calmette-Guérin Immunotherapy Response in Bladder Cancer : Where Are We Now?. Advances in Urology. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-455907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455907