Application of MicroRNA in Diagnosis and Treatment of Ovarian Cancer
Joint Authors
Nogami, Yuya
Iida, Miho
Adachi, Masataka
Nakamura, Kanako
Tominaga, Eiichiro
Kataoka, Fumio
Banno, Kouji
Kisu, Iori
Yanokura, Megumi
Umene, Kiyoko
Aoki, Daisuke
Nomura, Hiroyuki
Masuda, Kenta
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Ovarian cancer has a poor prognosis because early detection is difficult and recurrent ovarian cancer is usually drug-resistant.
The morbidity and mortality of ovarian cancer are high worldwide and new methods of diagnosis and therapy are needed.
MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression that are involved in carcinogenesis, metastasis, and invasion.
Thus, miRNAs are likely to be useful as diagnostic and prognostic biomarkers and for cancer therapy.
Many miRNAs have altered expression in ovarian cancer compared to normal ovarian tissues and these changes may be useful for diagnosis and treatment.
For example, deficiencies of enzymes including Dicer and Drosha that are required for miRNA biogenesis may be adverse prognostic factors; miRNAs such as miR-214 and miR-31, which are involved in drug resistance, and the miR-200 family, which is implicated in metastasis, may serve as biomarkers; and transfection of downregulated miRNAs and inhibition of upregulated miRNAs may be effective for treatment of ovarian cancer.
Chemotherapy targeting epigenetic mechanisms associated with miRNAs may also be effective to reverse gene silencing.
American Psychological Association (APA)
Banno, Kouji& Yanokura, Megumi& Iida, Miho& Adachi, Masataka& Nakamura, Kanako& Nogami, Yuya…[et al.]. 2014. Application of MicroRNA in Diagnosis and Treatment of Ovarian Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-455929
Modern Language Association (MLA)
Banno, Kouji…[et al.]. Application of MicroRNA in Diagnosis and Treatment of Ovarian Cancer. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-455929
American Medical Association (AMA)
Banno, Kouji& Yanokura, Megumi& Iida, Miho& Adachi, Masataka& Nakamura, Kanako& Nogami, Yuya…[et al.]. Application of MicroRNA in Diagnosis and Treatment of Ovarian Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-455929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455929