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Tumor-Stromal Interactions Influence Radiation Sensitivity in Epithelial- versus Mesenchymal-Like Prostate Cancer Cells
Joint Authors
Chung, Leland W. K.
Turner, Timothy
Wang, Ruoxiang
Yates, Clayton
Sharp, Starlette
Sung, Shian-Ying
Gururajan, Murali
Josson, Sajni
Johnstone, Peter A. S.
Aneja, Ritu
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
HS-27a human bone stromal cells, in 2D or 3D coultures, induced cellular plasticity in human prostate cancer ARCaPE and ARCaPM cells in an EMT model.
Cocultured ARCaPE or ARCaPM cells with HS-27a, developed increased colony forming capacity and growth advantage, with ARCaPE exhibiting the most significant increases in presence of bone or prostate stroma cells.
Prostate (Pt-N or Pt-C) or bone (HS-27a) stromal cells induced significant resistance to radiation treatment in ARCaPE cells compared to ARCaPM cells.
However pretreatment with anti-E-cadherin antibody (SHEP8-7) or anti-alpha v integrin blocking antibody (CNT095) significantly decreased stromal cell-induced radiation resistance in both ARCaPE- and ARCaPM-cocultured cells.
Taken together the data suggest that mesenchymal-like cancer cells reverting to epithelial-like cells in the bone microenvironment through interaction with bone marrow stromal cells and reexpress E-cadherin.
These cell adhesion molecules such as E-cadherin and integrin alpha v in cancer cells induce cell survival signals and mediate resistance to cancer treatments such as radiation.
American Psychological Association (APA)
Josson, Sajni& Sharp, Starlette& Sung, Shian-Ying& Johnstone, Peter A. S.& Aneja, Ritu& Wang, Ruoxiang…[et al.]. 2010. Tumor-Stromal Interactions Influence Radiation Sensitivity in Epithelial- versus Mesenchymal-Like Prostate Cancer Cells. Journal of Oncology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-455930
Modern Language Association (MLA)
Josson, Sajni…[et al.]. Tumor-Stromal Interactions Influence Radiation Sensitivity in Epithelial- versus Mesenchymal-Like Prostate Cancer Cells. Journal of Oncology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-455930
American Medical Association (AMA)
Josson, Sajni& Sharp, Starlette& Sung, Shian-Ying& Johnstone, Peter A. S.& Aneja, Ritu& Wang, Ruoxiang…[et al.]. Tumor-Stromal Interactions Influence Radiation Sensitivity in Epithelial- versus Mesenchymal-Like Prostate Cancer Cells. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-455930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455930