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Brd4 and HEXIM1 : Multiple Roles in P-TEFb Regulation and Cancer
Joint Authors
Chen, Ruichuan
Chao, Sheng-Hao
Yik, Jasper H. N.
Lew, Qiao Jing
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Bromodomain-containing protein 4 (Brd4) and hexamethylene bisacetamide (HMBA) inducible protein 1 (HEXIM1) are two opposing regulators of the positive transcription elongation factor b (P-TEFb), which is the master modulator of RNA polymerase II during transcriptional elongation.
While Brd4 recruits P-TEFb to promoter-proximal chromatins to activate transcription, HEXIM1 sequesters P-TEFb into an inactive complex containing the 7SK small nuclear RNA.
Besides regulating P-TEFb’s transcriptional activity, recent evidence demonstrates that both Brd4 and HEXIM1 also play novel roles in cell cycle progression and tumorigenesis.
Here we will discuss the current knowledge on Brd4 and HEXIM1 and their implication as novel therapeutic options against cancer.
American Psychological Association (APA)
Chen, Ruichuan& Yik, Jasper H. N.& Lew, Qiao Jing& Chao, Sheng-Hao. 2014. Brd4 and HEXIM1 : Multiple Roles in P-TEFb Regulation and Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-455936
Modern Language Association (MLA)
Chen, Ruichuan…[et al.]. Brd4 and HEXIM1 : Multiple Roles in P-TEFb Regulation and Cancer. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-455936
American Medical Association (AMA)
Chen, Ruichuan& Yik, Jasper H. N.& Lew, Qiao Jing& Chao, Sheng-Hao. Brd4 and HEXIM1 : Multiple Roles in P-TEFb Regulation and Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-455936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455936