Spectrum of Disorders Associated with Elevated Serum IgG4 Levels Encountered in Clinical Practice
Joint Authors
Peikert, Tobias
Sekiguchi, Hiroshi
Horie, Ryohei
Yi, Eunhee S.
Ryu, Jay H.
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
IgG4-related disease (IgG4-RD) is a recently described systemic fibroinflammatory disease associated with elevated circulating levels of IgG4 and manifests a wide spectrum of clinical presentations.
Although serum IgG4 level has been described to be the most sensitive and specific laboratory test for the diagnosis of IgG4-RD, it is recognized that an elevated serum IgG4 level can be encountered in other diseases.
In this study, we sought to identify the frequency of IgG4-RD and other disease associations in patients with elevated serum IgG4 levels seen in clinical practice.
Among 3,300 patients who underwent IgG subclass testing over a 2-year period from January 2009 to December 2010, 158 (4.8%) had an elevated serum IgG4 level (>140 mg/dL).
IgG4 subclass testing was performed for evaluation of suspected IgG4-RD or immunodeficiency.
Twenty-nine patients (18.4%) had definite or possible IgG4-RD.
Among those patients without IgG4-RD, a broad spectrum of biliary tract, pancreatic, liver, and lung diseases, as well as systemic vasculitis, was diagnosed.
We conclude that patients with elevated serum IgG4 levels encountered in clinical practice manifest a wide array of disorders, and only a small minority of them has IgG4-RD.
American Psychological Association (APA)
Ryu, Jay H.& Horie, Ryohei& Sekiguchi, Hiroshi& Peikert, Tobias& Yi, Eunhee S.. 2012. Spectrum of Disorders Associated with Elevated Serum IgG4 Levels Encountered in Clinical Practice. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-455943
Modern Language Association (MLA)
Ryu, Jay H.…[et al.]. Spectrum of Disorders Associated with Elevated Serum IgG4 Levels Encountered in Clinical Practice. International Journal of Rheumatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-455943
American Medical Association (AMA)
Ryu, Jay H.& Horie, Ryohei& Sekiguchi, Hiroshi& Peikert, Tobias& Yi, Eunhee S.. Spectrum of Disorders Associated with Elevated Serum IgG4 Levels Encountered in Clinical Practice. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-455943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455943