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Glix 13, a New Drug Acting on Glutamatergic Pathways in Children and Animal Models of Autism Spectrum Disorders
Joint Authors
Sogos, Carla
Olabinjo, Yinka
Santini, Annamaria Chiara
Iorio, Rosamaria
Gerlini, Raffaele
Giovanna Maria, Pierantoni
Di Domenico, Marina
Giovane, Alfonso
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Recently standardized diagnostic instruments have been developed in diagnostic and therapeutic procedures for Autism Spectrumv Disorders (ASD).
According to the DSM-5 criteria, individuals with ASD must show symptoms from early childhood.
These symptoms are communication deficits and restricted, repetitive patterns of behaviour.
It was recently described by Bioinformatic analysis that 99 modified genes were associated with human autism.
Gene expression patterns in the low-line animals show significant enrichment in autism-associated genes and the NMDA receptor gene family was identified among these.
Using ultrasonic vocalizations, it was demonstrated that genetic variation has a direct impact on the expression of social interactions.
It has been proposed that specific alleles interact with a social reward process in the adolescent mouse modifying their social interaction and their approach toward each other.
In this review we report that the monoclonal antibody-derived tetrapeptide GLYX-13 was found to act as an N-methyl-D-aspartate receptor modulator and possesses the ability to readily cross the blood brain barrier.
Treatment with the NMDAR glycine site partial agonist GLYX-13 rescued the deficit in the animal model.
Thus, the NMDA receptor has been shown to play a functional role in autism, and GLYX-13 shows promise for the treatment of autism in autistic children.
American Psychological Association (APA)
Santini, Annamaria Chiara& Giovanna Maria, Pierantoni& Gerlini, Raffaele& Iorio, Rosamaria& Olabinjo, Yinka& Giovane, Alfonso…[et al.]. 2014. Glix 13, a New Drug Acting on Glutamatergic Pathways in Children and Animal Models of Autism Spectrum Disorders. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-455970
Modern Language Association (MLA)
Santini, Annamaria Chiara…[et al.]. Glix 13, a New Drug Acting on Glutamatergic Pathways in Children and Animal Models of Autism Spectrum Disorders. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-455970
American Medical Association (AMA)
Santini, Annamaria Chiara& Giovanna Maria, Pierantoni& Gerlini, Raffaele& Iorio, Rosamaria& Olabinjo, Yinka& Giovane, Alfonso…[et al.]. Glix 13, a New Drug Acting on Glutamatergic Pathways in Children and Animal Models of Autism Spectrum Disorders. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-455970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455970