Bcl-2 Family Proteins Are Involved in the Signal Crosstalk between Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Tumor Chemotherapy Resistance
Joint Authors
Zhou, Lei
Su, Jing
Xiang, Xi-yan
Xia, Mei-hui
Sun, Lian-kun
Xu, Ye
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Tumor cells overexpress antiapoptotic proteins of the Bcl-2 (B-cell leukemia/lymphoma-2) family, which can lead to both escape from cell death and resistance to chemotherapeutic drugs.
Recent studies suggest that the endoplasmic reticulum (ER) can produce proapoptotic signals, amplifying the apoptotic signaling cascade.
The crosstalk between mitochondria and ER plays a decisive role in many cellular events but especially in cell death.
Bcl-2 family proteins located in the ER and mitochondria can influence not only the function of the two organelles but also the interaction between them.
Therefore, the Bcl-2 family of proteins may also be involved in the mechanism of tumor chemotherapy resistance by influencing crosstalk between the ER and mitochondria.
In this review we will briefly discuss evidence to support this concept.
American Psychological Association (APA)
Su, Jing& Zhou, Lei& Xia, Mei-hui& Xu, Ye& Xiang, Xi-yan& Sun, Lian-kun. 2014. Bcl-2 Family Proteins Are Involved in the Signal Crosstalk between Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Tumor Chemotherapy Resistance. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-455975
Modern Language Association (MLA)
Su, Jing…[et al.]. Bcl-2 Family Proteins Are Involved in the Signal Crosstalk between Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Tumor Chemotherapy Resistance. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-455975
American Medical Association (AMA)
Su, Jing& Zhou, Lei& Xia, Mei-hui& Xu, Ye& Xiang, Xi-yan& Sun, Lian-kun. Bcl-2 Family Proteins Are Involved in the Signal Crosstalk between Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Tumor Chemotherapy Resistance. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-455975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455975