![](/images/graphics-bg.png)
Obstructive Sleep Apnea, Oxidative Stress and Cardiovascular Disease : Lessons from Animal Studies
Joint Authors
Dumitrascu, Rio
Schulz, Richard
Weissmann, Norbert
Heitmann, Joerg
Seeger, Werner
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular (CV) diseases such as arterial hypertension, heart failure, and stroke.
Based on human research, sympathetic activation, inflammation, and oxidative stress are thought to play major roles in the pathophysiology of OSA-related CV diseases.
Animal models of OSA have shown that endothelial dysfunction, vascular remodelling, and systemic and pulmonary arterial hypertension as well as heart failure can develop in response to chronic intermittent hypoxia (CIH).
The available animal data are clearly in favour of oxidative stress playing a key role in the development of all of these CV manifestations of OSA.
Presumably, the oxidative stress is due to an activation of NADPH oxidase and other free oxygen radicals producing enzymes within the CV system as evidenced by data from knockout mice and pharmacological interventions.
It is hoped that animal models of OSA-related CV disease will continue to contribute to a deeper understanding of their underlying pathophysiology and will foster the way for the development of cardioprotective treatment options other than conventional CPAP therapy.
American Psychological Association (APA)
Dumitrascu, Rio& Heitmann, Joerg& Seeger, Werner& Weissmann, Norbert& Schulz, Richard. 2013. Obstructive Sleep Apnea, Oxidative Stress and Cardiovascular Disease : Lessons from Animal Studies. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-455993
Modern Language Association (MLA)
Dumitrascu, Rio…[et al.]. Obstructive Sleep Apnea, Oxidative Stress and Cardiovascular Disease : Lessons from Animal Studies. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-455993
American Medical Association (AMA)
Dumitrascu, Rio& Heitmann, Joerg& Seeger, Werner& Weissmann, Norbert& Schulz, Richard. Obstructive Sleep Apnea, Oxidative Stress and Cardiovascular Disease : Lessons from Animal Studies. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-455993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455993