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Propagation of Blood Function Errors to the Estimates of Kinetic Parameters with Dynamic PET
Joint Authors
Yetik, İmam Şamil
Cheng, Yafang
Source
International Journal of Biomedical Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-11-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Dynamic PET, in contrast to static PET, can identify temporal variations in the radiotracer concentration.
Mathematical modeling of the tissue of interest in dynamic PET can be simplified using compartment models as a linear system where the time activity curve of a specific tissue is the convolution of the tracer concentration in the plasma and the impulse response of the tissue containing kinetic parameters.
Since the arterial sampling of blood to acquire the value of tracer concentration is invasive, blind methods to estimate both blood input function and kinetic parameters have recently drawn attention.
Several methods have been developed, but the effect of accuracy of the estimated blood function on the estimation of the kinetic parameters is not studied.
In this paper, we present a method to compute the error in the kinetic parameter estimates caused by the error in the blood input function.
Computer simulations show that analytical expressions we derive are sufficiently close to results obtained from numerical methods.
Our findings are important to observe the effect of the blood function on kinetic parameter estimation, but also useful to evaluate various blind methods and observe the dependence of kinetic parameter estimates to certain parts of the blood function.
American Psychological Association (APA)
Cheng, Yafang& Yetik, İmam Şamil. 2010. Propagation of Blood Function Errors to the Estimates of Kinetic Parameters with Dynamic PET. International Journal of Biomedical Imaging،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-455996
Modern Language Association (MLA)
Cheng, Yafang& Yetik, İmam Şamil. Propagation of Blood Function Errors to the Estimates of Kinetic Parameters with Dynamic PET. International Journal of Biomedical Imaging No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-455996
American Medical Association (AMA)
Cheng, Yafang& Yetik, İmam Şamil. Propagation of Blood Function Errors to the Estimates of Kinetic Parameters with Dynamic PET. International Journal of Biomedical Imaging. 2010. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-455996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455996