Effect of Ghrelin on Glucose-Insulin Homeostasis : Therapeutic Implications
Joint Authors
Cordido, Fernando
Sangiao-Alvarellos, Susana
Source
International Journal of Peptides
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-09
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
Ghrelin is a 28-amino-acid peptide that displays a strong growth hormone- (GH-) releasing activity through the activation of the growth hormone secretagogue receptor (GHSR).
The first studies about role of ghrelin were focused on its orexigenic ability, but despite indisputable pharmacological data, the evidence for a physiological role for ghrelin in the control of appetite is much less clear.
Mice with targeted deletion of either ghrelin or the GHSR exhibit an essentially normal metabolic phenotype when fed a regular chow diet, suggesting that ghrelin may have a redundant role in the regulation of food intake.
RNAs for ghrelin as well as GHSR are expressed in the pancreas of rats and humans and several studies propose that ghrelin could have an important function in glucose homeostasis and insulin release, independent of GH secretion.
Low plasma ghrelin levels are associated with elevated fasting insulin levels and insulin resistance, suggesting both physiological and pathophysiological roles for ghrelin.
For this reason, at least theoretically, ghrelin and/or its signalling manipulation could be useful for the treatment or prevention of diseases of glucose homeostasis such as type 2 diabetes.
American Psychological Association (APA)
Sangiao-Alvarellos, Susana& Cordido, Fernando. 2010. Effect of Ghrelin on Glucose-Insulin Homeostasis : Therapeutic Implications. International Journal of Peptides،Vol. 2010, no. 2010, pp.1-25.
https://search.emarefa.net/detail/BIM-456000
Modern Language Association (MLA)
Sangiao-Alvarellos, Susana& Cordido, Fernando. Effect of Ghrelin on Glucose-Insulin Homeostasis : Therapeutic Implications. International Journal of Peptides No. 2010 (2010), pp.1-25.
https://search.emarefa.net/detail/BIM-456000
American Medical Association (AMA)
Sangiao-Alvarellos, Susana& Cordido, Fernando. Effect of Ghrelin on Glucose-Insulin Homeostasis : Therapeutic Implications. International Journal of Peptides. 2010. Vol. 2010, no. 2010, pp.1-25.
https://search.emarefa.net/detail/BIM-456000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456000