Adrenocortical Carcinoma : Current Therapeutic State-of-the-Art
Joint Authors
Carling, Tobias
Lebastchi, Amir H.
Kunstman, John W.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy that generally conveys a poor prognosis.
Currently, surgical resection is considered the lone curative treatment modality.
In addition, the low prevalence of ACC has limited effective clinical trial design to develop evidence-based approaches to ACC therapy.
The proper role of radio- and chemotherapy treatment for ACC is still being defined.
Similarly, the molecular pathogenesis of ACC remains to be fully characterized.
Despite these challenges, progress has been made in several areas.
After years of refinement, an internationally accepted staging system has been defined.
International collaborations have facilitated increasingly robust clinical trials, especially regarding agent choice and patient selection for chemotherapeutics.
Genetic array data and molecular profiling have identified new potential targets for rational drug design as well as potential tumor markers and predictors of therapeutic response.
However, these advances have not yet been translated into a large outcomes benefit for ACC patients.
In this paper, we summarize established therapy for ACC and highlight recent findings in the field that are impacting clinical practice.
American Psychological Association (APA)
Lebastchi, Amir H.& Kunstman, John W.& Carling, Tobias. 2012. Adrenocortical Carcinoma : Current Therapeutic State-of-the-Art. Journal of Oncology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-456001
Modern Language Association (MLA)
Lebastchi, Amir H.…[et al.]. Adrenocortical Carcinoma : Current Therapeutic State-of-the-Art. Journal of Oncology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-456001
American Medical Association (AMA)
Lebastchi, Amir H.& Kunstman, John W.& Carling, Tobias. Adrenocortical Carcinoma : Current Therapeutic State-of-the-Art. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-456001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456001