Mitochondrial Acetylation and Diseases of Aging
Joint Authors
Wagner, Gregory R.
Payne, R. Mark
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
In recent years, protein lysine acetylation has emerged as a prominent and conserved regulatory posttranslational modification that is abundant on numerous enzymes involved in the processes of intermediary metabolism.
Well-characterized mitochondrial processes of carbon utilization are enriched in acetyl-lysine modifications.
Although seminal discoveries have been made in the basic biology of mitochondrial acetylation, an understanding of how acetylation states influence enzyme function and metabolic reprogramming during pathological states remains largely unknown.
This paper will examine our current understanding of eukaryotic acetate metabolism and present recent findings in the field of mitochondrial acetylation biology.
The implications of mitochondrial acetylation for the aging process will be discussed, as well as its potential implications for the unique and localized metabolic states that occur during the aging-associated conditions of heart failure and cancer growth.
American Psychological Association (APA)
Wagner, Gregory R.& Payne, R. Mark. 2011. Mitochondrial Acetylation and Diseases of Aging. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-456015
Modern Language Association (MLA)
Wagner, Gregory R.& Payne, R. Mark. Mitochondrial Acetylation and Diseases of Aging. Journal of Aging Research No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-456015
American Medical Association (AMA)
Wagner, Gregory R.& Payne, R. Mark. Mitochondrial Acetylation and Diseases of Aging. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-456015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456015