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Role of PPARs in Radiation-Induced Brain Injury
Joint Authors
Ramanan, Sriram
Robbins, Michael E. C.
Riddle, David R.
Zhao, Weiling
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Whole-brain irradiation (WBI) represents the primary mode of treatment for brain metastases; about 200 000 patients receive WBI each year in the USA.
Up to 50% of adult and 100% of pediatric brain cancer patients who survive >6 months post-WBI will suffer from a progressive, cognitive impairment.
At present, there are no proven long-term treatments or preventive strategies for this significant radiation-induced late effect.
Recent studies suggest that the pathogenesis of radiation-induced brain injury involves WBI-mediated increases in oxidative stress and/or inflammatory responses in the brain.
Therefore, anti-inflammatory strategies can be employed to modulate radiation-induced brain injury.
Peroxisomal proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the steroid/thyroid hormone nuclear receptor superfamily.
Although traditionally known to play a role in metabolism, increasing evidence suggests a role for PPARs in regulating the response to inflammation and oxidative injury.
PPAR agonists have been shown to cross the blood-brain barrier and confer neuroprotection in animal models of CNS disorders such as stroke, multiple sclerosis and Parkinson's disease.
However, the role of PPARs in radiation-induced brain injury is unclear.
In this manuscript, we review the current knowledge and the emerging insights about the role of PPARs in modulating radiation-induced brain injury.
American Psychological Association (APA)
Ramanan, Sriram& Zhao, Weiling& Riddle, David R.& Robbins, Michael E. C.. 2009. Role of PPARs in Radiation-Induced Brain Injury. PPAR Research،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-456023
Modern Language Association (MLA)
Ramanan, Sriram…[et al.]. Role of PPARs in Radiation-Induced Brain Injury. PPAR Research No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-456023
American Medical Association (AMA)
Ramanan, Sriram& Zhao, Weiling& Riddle, David R.& Robbins, Michael E. C.. Role of PPARs in Radiation-Induced Brain Injury. PPAR Research. 2009. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-456023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456023