Circulating 25-Hydroxyvitamin D Levels in Fully Breastfed Infants on Oral Vitamin D Supplementation

Abstract EN

Objective.

To examine the effectiveness of oral vitamin D3 (400 IU) supplementation on the nutritional vitamin D status of breastfeeding infants.

Design.

As part of a larger ongoing vitamin D RCT trial of lactating women, infants of mothers assigned to control received 1 drop of 400 IU vitamin D3/day starting at one month of age.

Infant 25(OH)D levels (mean ± S.D.) were measured by RIA at visits 1, 4, and 7.

Results.

The infant mean ± S.D.

25(OH)D at baseline was 16.0 ± 9.3 ng/mL (range 1.0–40.8; n=33); 24 (72.7%) had baseline levels <20 ng/mL (consistent with deficiency).

The mean levels increased to 43.6 ± 14.1 (range 18.2–69.7) at 4 months and remained relatively unchanged at month 7: 42.5 ± 12.1 ng/mL (range 18.9–67.2).

The change in values between 1 and 4 months and 1 and 7 months was statistically significant (P≤.0001), and despite a decrease in dose per kilogram, values were not significantly different between months 4 and 7 (P=.66).

Conclusions.

Oral vitamin D3 supplementation as an oil emulsion was associated with significant and sustained increases in 25(OH)D from baseline in fully breastfeeding infants through 7 months.