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Equal Force Recovery in Dysferlin-Deficient and Wild-Type Muscles Following Saponin Exposure
Joint Authors
de Tombe, Pieter P.
Ait-Mou, Younss
Xu, Li
Han, Renzhi
Zhao, Piming
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dysferlin plays an important role in repairing membrane damage elicited by laser irradiation, and dysferlin deficiency causes muscular dystrophy and associated cardiomyopathy.
Proteins such as perforin, complement component C9, and bacteria-derived cytolysins, as well as the natural detergent saponin, can form large pores on the cell membrane via complexation with cholesterol.
However, it is not clear whether dysferlin plays a role in repairing membrane damage induced by pore-forming reagents.
In this study, we observed that dysferlin-deficient muscles recovered the tetanic force production to the same extent as their WT counterparts following a 5-min saponin exposure (50 μg/mL).
Interestingly, the slow soleus muscles recovered significantly better than the fast extensor digitorum longus (EDL) muscles.
Our data suggest that dysferlin is unlikely involved in repairing saponin-induced membrane damage and that the slow muscle is more efficient than the fast muscle in repairing such damage.
American Psychological Association (APA)
Zhao, Piming& Xu, Li& Ait-Mou, Younss& de Tombe, Pieter P.& Han, Renzhi. 2011. Equal Force Recovery in Dysferlin-Deficient and Wild-Type Muscles Following Saponin Exposure. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-456044
Modern Language Association (MLA)
Zhao, Piming…[et al.]. Equal Force Recovery in Dysferlin-Deficient and Wild-Type Muscles Following Saponin Exposure. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-456044
American Medical Association (AMA)
Zhao, Piming& Xu, Li& Ait-Mou, Younss& de Tombe, Pieter P.& Han, Renzhi. Equal Force Recovery in Dysferlin-Deficient and Wild-Type Muscles Following Saponin Exposure. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-456044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456044