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The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils
Joint Authors
Sehmi, Roma
Smith, Steven G.
Gauvreau, Gail M.
Imaoka, Haruki
Punia, Neha
Irshad, Anam
Janssen, Luke L.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
PPARγ agonists can either enhance or inhibit eosinophil migration, which is a sum of directional migration (chemotaxis) and random cell movement (chemokinesis).
To date, the effects of PPAR agonists on chemokinesis have not been examined.
This study investigates the effects of PPARα, δ, and γ agonists on eosinophil migration and chemokinesis.
Eosinophils purified from blood of atopic donors were preincubated with rosiglitazone (PPARγ agonist), GW9578 (PPARα agonist), GW501516 (PPARδ agonist), or diluent.
The effects of PPAR agonists were examined on eosinophil chemokinesis, eotaxin-induced migration of eosinophils, and migration of IL-5Rα+ CD34+ cells.
Expressions of CCR3, phospho-p38, phospho-ERK, and calcium release were also measured in eosinophils after rosiglitazone treatment.
Low concentrations of rosiglitazone, but not GW9578 or GW501516, increased chemokinesis of eosinophils (P=0.0038), and SDF-1α-induced migration of immature eosinophils (P=0.0538).
Rosiglitazone had an effect on eosinophil calcium flux but had no effect on expression of CCR3 or phosphorylation of p38 or ERK.
In contrast, high concentrations of rosiglitazone inhibited eosinophil migration (P=0.0042).
The effect of rosiglitazone on eosinophil migration and chemokinesis appears to be through modification of calcium signaling, which alludes to a novel PPAR-mediated mechanism to modulate eosinophil function.
American Psychological Association (APA)
Smith, Steven G.& Imaoka, Haruki& Punia, Neha& Irshad, Anam& Janssen, Luke L.& Sehmi, Roma…[et al.]. 2012. The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils. PPAR Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-456045
Modern Language Association (MLA)
Smith, Steven G.…[et al.]. The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils. PPAR Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-456045
American Medical Association (AMA)
Smith, Steven G.& Imaoka, Haruki& Punia, Neha& Irshad, Anam& Janssen, Luke L.& Sehmi, Roma…[et al.]. The Effect of PPAR Agonists on the Migration of Mature and Immature Eosinophils. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-456045
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456045