Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids
Joint Authors
Kawashima, Etsuko
Terui, Yusuke
Ohba, Yusuke
Kamaike, Kazuo
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Pyrrolepolyamide-2′-deoxyguanosine hybrids (Hybrid 2 and Hybrid 3) incorporating the 3-aminopropionyl or 3-aminopropyl linker were designed and synthesized on the basis of previously reported results of a pyrrolepolyamide-adenosine hybrid (Hybrid 1).
Evaluation of the DNA binding sequence selectivity of pyrrolepolyamide-2′-deoxyguanosine hybrids was performed by CD spectral and Tm analyses.
It was shown that Hybrid 3 possessed greater binding specificity than distamycin A, Hybrid 1 and Hybrid 2.
American Psychological Association (APA)
Kawashima, Etsuko& Ohba, Yusuke& Terui, Yusuke& Kamaike, Kazuo. 2010. Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-456048
Modern Language Association (MLA)
Kawashima, Etsuko…[et al.]. Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids. Journal of Nucleic Acids No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-456048
American Medical Association (AMA)
Kawashima, Etsuko& Ohba, Yusuke& Terui, Yusuke& Kamaike, Kazuo. Design, Synthesis, and Analysis of Minor Groove Binder Pyrrolepolyamide-2′-Deoxyguanosine Hybrids. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-456048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456048
