Immunoreactivity of the 14F7 Mab (Raised against N-Glycolyl GM3 Ganglioside) as a Positive Prognostic Factor in Non-Small-Cell Lung Cancer
Joint Authors
Calzado, Enrique Rengifo
Cedeño, Mercedes
Carr, Adriana
Rengifo, Charles E.
Blanco, Rancés
Frómeta, Milagros
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Lung carcinoma is the leading cause of cancer-related mortality worldwide.
Therefore, numerous studies are focusing on the assessment of other biological and molecular prognostic factors in these tumors.
We evaluated the relationship between 14F7 Mab reactivity, pathological features, DNA-content and S-phase fraction (SPF), and their impact in the survival of NSCLC patients.
Hematoxylin and eosin staining and immunohistochemistry optical microscopy assays as well as DNA content and SPF measuring using flow cytometry were performed.
The 14F7 reactivity was widely observed in NSCLC sections, no depending of the clinicopathological characteristics.
We also obtained differences in the intensity of reaction with 14F7 as well as in the SPF between diploid and aneuploid carcinomas.
Patients with diploid tumors showing higher SPF and 14F7 reaction joint to a low mitotic index displayed higher survival rates.
Our results are in agreement with the assumption of the possible positive prognostic value of 14F7 staining in NSCLC.
American Psychological Association (APA)
Blanco, Rancés& Rengifo, Charles E.& Cedeño, Mercedes& Frómeta, Milagros& Calzado, Enrique Rengifo& Carr, Adriana. 2012. Immunoreactivity of the 14F7 Mab (Raised against N-Glycolyl GM3 Ganglioside) as a Positive Prognostic Factor in Non-Small-Cell Lung Cancer. Pathology Research International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-456063
Modern Language Association (MLA)
Blanco, Rancés…[et al.]. Immunoreactivity of the 14F7 Mab (Raised against N-Glycolyl GM3 Ganglioside) as a Positive Prognostic Factor in Non-Small-Cell Lung Cancer. Pathology Research International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-456063
American Medical Association (AMA)
Blanco, Rancés& Rengifo, Charles E.& Cedeño, Mercedes& Frómeta, Milagros& Calzado, Enrique Rengifo& Carr, Adriana. Immunoreactivity of the 14F7 Mab (Raised against N-Glycolyl GM3 Ganglioside) as a Positive Prognostic Factor in Non-Small-Cell Lung Cancer. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-456063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456063