Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children
Joint Authors
Cho, Won Kyoung
Park, So Hyun
Choi, Hee-Baeg
Kim, Tai-Gyu
Jung, Min Ho
Baek, In Cheol
Suh, Byung-Kyu
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Major histocompatibility complex class I chain-related gene A (MICA) is a ligand for the activating NKG2D receptor expressed on natural killer (NK) cells.
We aimed to assess the association of MICA polymorphism with autoimmune thyroid disease (AITD) in Korean children.
Methods.
Eighty-one patients with AITD were recruited.
We analyzed MICA polymorphisms by PCR-SSP and compared the results with those of 70 healthy controls.
Results.
In AITD, the allele frequencies of MICA*010 (OR=2.21; 95% CI, 1.30–3.76, P<0.003, Pc<0.042) were higher than those of controls.
Patients who did not have thyroid-associated ophthalmopathy showed higher frequencies of MICA*010 (OR=2.99; 95% CI, 1.47–6.08, P<0.003, Pc<0.042) and lower frequencies of MICA*008 (OR=0.08; 95% CI, 0.01–0.62, P<0.001, Pc<0.014) compared to those of controls.
HLA-B*46, which shows the strongest association with AITD compared with other HLA alleles, showed the strongest linkage disequilibrium with MICA*010.
Analyses of the associations between MICA*010 and HLA-B*46 with AITD suggest an association of the MICA allele with AITD.
Conclusions.
Our results suggest that innate immunity might contribute to the pathogenesis of AITD.
American Psychological Association (APA)
Cho, Won Kyoung& Jung, Min Ho& Park, So Hyun& Baek, In Cheol& Choi, Hee-Baeg& Kim, Tai-Gyu…[et al.]. 2012. Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-456078
Modern Language Association (MLA)
Cho, Won Kyoung…[et al.]. Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children. International Journal of Endocrinology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-456078
American Medical Association (AMA)
Cho, Won Kyoung& Jung, Min Ho& Park, So Hyun& Baek, In Cheol& Choi, Hee-Baeg& Kim, Tai-Gyu…[et al.]. Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-456078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456078