Functional Development of the Circadian Clock in the Zebrafish Pineal Gland
Joint Authors
Ben-Moshe, Zohar
Foulkes, Nicholas S.
Gothilf, Yoav
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The zebrafish constitutes a powerful model organism with unique advantages for investigating the vertebrate circadian timing system and its regulation by light.
In particular, the remarkably early and rapid development of the zebrafish circadian system has facilitated exploring the factors that control the onset of circadian clock function during embryogenesis.
Here, we review our understanding of the molecular basis underlying functional development of the central clock in the zebrafish pineal gland.
Furthermore, we examine how the directly light-entrainable clocks in zebrafish cell lines have facilitated unravelling the general mechanisms underlying light-induced clock gene expression.
Finally, we summarize how analysis of the light-induced transcriptome and miRNome of the zebrafish pineal gland has provided insight into the regulation of the circadian system by light, including the involvement of microRNAs in shaping the kinetics of light- and clock-regulated mRNA expression.
The relative contributions of the pineal gland central clock and the distributed peripheral oscillators to the synchronization of circadian rhythms at the whole animal level are a crucial question that still remains to be elucidated in the zebrafish model.
American Psychological Association (APA)
Ben-Moshe, Zohar& Foulkes, Nicholas S.& Gothilf, Yoav. 2014. Functional Development of the Circadian Clock in the Zebrafish Pineal Gland. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-456088
Modern Language Association (MLA)
Ben-Moshe, Zohar…[et al.]. Functional Development of the Circadian Clock in the Zebrafish Pineal Gland. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-456088
American Medical Association (AMA)
Ben-Moshe, Zohar& Foulkes, Nicholas S.& Gothilf, Yoav. Functional Development of the Circadian Clock in the Zebrafish Pineal Gland. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-456088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456088