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Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease
Joint Authors
Ong, Tze-Zen
Razlan, Hamizah
Mahadeva, Sanjiv
Marzuki, Nurhayaty Muhamad
Shamsul, Azhar-Shah
Tai, Mei-Ling Sharon
Source
Gastroenterology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The accuracy of the 13C-methacetin breath test (13C-MBT) in differentiating between various stages of liver disease is not clear.
A cross-sectional study of Asian patients was conducted to examine the predictive value of the 13C-MBT in various stages of chronic liver diseases.
Diagnostic accuracy of the breath test was determined by sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve analysis.
Seventy-seven patients (47 men/30 women, mean age 50±16 years) were recruited.
Forty-seven patients had liver cirrhosis (Child Pugh A = 11, Child Pugh B = 15, and Child Pugh C = 21), 21 had fibrosis, and 9 had chronic inflammation.
The sensitivity and positive predictive value for liver fibrosis, cirrhosis (all stages), Child-Pugh A, Child-Pugh B, and Child-Pugh C were 65% and 56%, 89% and 89%, 67% and 42%, 40% and 40%, and 50% and 77%, respectively.
Area under curve values for fibrosis was 0.62 (0.39–0.86), whilst that for cirrhosis (all stages) was 0.95 (0.91–0.99).
The 13C-methacetin breath test has a poor predictive value for liver fibrosis but accurately determines advanced cirrhosis.
American Psychological Association (APA)
Razlan, Hamizah& Marzuki, Nurhayaty Muhamad& Tai, Mei-Ling Sharon& Shamsul, Azhar-Shah& Ong, Tze-Zen& Mahadeva, Sanjiv. 2011. Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease. Gastroenterology Research and Practice،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-456089
Modern Language Association (MLA)
Razlan, Hamizah…[et al.]. Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease. Gastroenterology Research and Practice No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-456089
American Medical Association (AMA)
Razlan, Hamizah& Marzuki, Nurhayaty Muhamad& Tai, Mei-Ling Sharon& Shamsul, Azhar-Shah& Ong, Tze-Zen& Mahadeva, Sanjiv. Diagnostic Value of the 13C Methacetin Breath Test in Various Stages of Chronic Liver Disease. Gastroenterology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-456089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456089