Prophylactic Administration of Surfactant in Extremely Premature Infants
Joint Authors
Koch, Lutz
Ruef, Peter
Poeschl, Johannes
Beedgen, Bernd
Frommhold, David
Source
Critical Care Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To investigate whether prophylactic surfactant administration is superior over selective treatment in preterm infants with respiratory distress syndrome (RDS).
Methods.
In our retrospective analysis, we compared premature infants (23 + 0 to 26 + 6 weeks) receiving 200 mg/kg surfactant (curosurf®) within five minutes after birth (prophylactic group, N=31) with those infants who received surfactant therapy for established RDS (selective group, N=34).
Results.
Prophylactic therapy significantly decreased the need for mechanical ventilation (74 hours per patient versus 171 hours per patient, resp.).
We observed a reduced incidence of interstitial emphysema (0% versus 9%, resp.), pneumothoraces (3% versus 9%, resp.), chronic lung disease (26% versus 38%, resp.), and surfactant doses per patient (1.3 versus 1.8, resp.), although those variables did not reach significance.
Conclusion.
We conclude that infants under 27 weeks' gestation profit from prophylactic surfactant administration by reducing the time of mechanical ventilation.
This in turn could contribute to reduce the risk for mechanical ventilation associated complications, without any detrimental short-term side effects.
American Psychological Association (APA)
Koch, Lutz& Frommhold, David& Beedgen, Bernd& Ruef, Peter& Poeschl, Johannes. 2010. Prophylactic Administration of Surfactant in Extremely Premature Infants. Critical Care Research and Practice،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-456103
Modern Language Association (MLA)
Koch, Lutz…[et al.]. Prophylactic Administration of Surfactant in Extremely Premature Infants. Critical Care Research and Practice No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-456103
American Medical Association (AMA)
Koch, Lutz& Frommhold, David& Beedgen, Bernd& Ruef, Peter& Poeschl, Johannes. Prophylactic Administration of Surfactant in Extremely Premature Infants. Critical Care Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-456103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456103