The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation
Joint Authors
Sperling, Anne I.
Williams, Jesse W.
Tjota, Melissa Y.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In both human asthmatics and animal models of allergy, allergen-specific IgG can contribute to Th2-mediated allergic inflammation.
Mouse models have elucidated an important role for IgG and Fc-gamma receptor (FcγR) signaling on antigen presenting cells (APC) for the induction of airway inflammation.
These studies suggest a positive feedback loop between IgG produced by the adaptive B cell response and FcγR signaling on innate immune cells.
Studies of IgG and FcγRs in humans with asthma or allergic lung disease have been more controversial.
Some reports have identified associations between allergen-specific IgG and severity of allergic responses, while other studies have found associations of IgG subclass IgG4 with allergic tolerance.
In this paper, we review the literature to help define the nature of IgG and FcγR signaling on innate immune cells and how it contributes to the development of allergic immune responses.
American Psychological Association (APA)
Williams, Jesse W.& Tjota, Melissa Y.& Sperling, Anne I.. 2012. The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation. Journal of Allergy،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-456116
Modern Language Association (MLA)
Williams, Jesse W.…[et al.]. The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation. Journal of Allergy No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-456116
American Medical Association (AMA)
Williams, Jesse W.& Tjota, Melissa Y.& Sperling, Anne I.. The Contribution of Allergen-Specific IgG to the Development of Th2-Mediated Airway Inflammation. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-456116
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456116