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Three-Dimensional Culture of Human Embryonic Stem Cell Derived Hepatic Endoderm and Its Role in Bioartificial Liver Construction
Joint Authors
Greenhough, Sebastian
Hay, David Colin
Sharma, Ruchi
Medine, Claire N.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The liver carries out a range of functions essential for bodily homeostasis.
The impairment of liver functions has serious implications and is responsible for high rates of patient morbidity and mortality.
Presently, liver transplantation remains the only effective treatment, but donor availability is a major limitation.
Therefore, artificial and bioartificial liver devices have been developed to bridge patients to liver transplantation.
Existing support devices improve hepatic encephalopathy to a certain extent; however their usage is associated with side effects.
The major hindrance in the development of bioartificial liver devices and cellular therapies is the limited availability of human hepatocytes.
Moreover, primary hepatocytes are difficult to maintain and lose hepatic identity and function over time even with sophisticated tissue culture media.
To overcome this limitation, renewable cell sources are being explored.
Human embryonic stem cells are one such cellular resource and have been shown to generate a reliable and reproducible supply of human hepatic endoderm.
Therefore, the use of human embryonic stem cell-derived hepatic endoderm in combination with tissue engineering has the potential to pave the way for the development of novel bioartificial liver devices and predictive drug toxicity assays.
American Psychological Association (APA)
Sharma, Ruchi& Greenhough, Sebastian& Medine, Claire N.& Hay, David Colin. 2010. Three-Dimensional Culture of Human Embryonic Stem Cell Derived Hepatic Endoderm and Its Role in Bioartificial Liver Construction. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-456123
Modern Language Association (MLA)
Sharma, Ruchi…[et al.]. Three-Dimensional Culture of Human Embryonic Stem Cell Derived Hepatic Endoderm and Its Role in Bioartificial Liver Construction. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-456123
American Medical Association (AMA)
Sharma, Ruchi& Greenhough, Sebastian& Medine, Claire N.& Hay, David Colin. Three-Dimensional Culture of Human Embryonic Stem Cell Derived Hepatic Endoderm and Its Role in Bioartificial Liver Construction. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-456123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456123