Disseminated Exfoliative Dermatitis Associated with All-Transretinoic Acid in the Treatment of Acute Promyelocytic Leukemia
Joint Authors
Hulya, Dogru
Melih, Aktan
Ipek, Yonal
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-17
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Acute promyelocytic leukemia (APL) is a biologically and clinically separate type of acute myeloid leukemia characterized by a translocation involving the retinoic acid receptor-alpha (RARa) locus on chromosome 17, the great majority of which is t(15; 17)(q24.1; q21.1) (Collins (1998), Melnick and Licht (1999), and Grimwade (1999)).
Retinoic acid is a critical ligand in the differentiation pathway of multiple tissues, mediated through binding to an RAR.
All-trans retinoic acid (ATRA) is a subgroup of the retinoid family, which induces complete remission (CR) in APL by causing differentiation and apoptosis in immature malignant promyelocytes rather than inducing cell death by cytotoxicity (Warrell et al.
(1993), Liu et al.
(2000), and Cassinat et al.
(2001)).
ATRA-associated toxicity consisting of headache, fever, weakness, fatigue, dry skin, dermatitis, gastrointestinal disorders, and hypertriglyceridemia has been shown to be mild (Kurzrock et al.
(1993)).
Herein, we describe a patient with APL that developed an erythematous reaction of the whole body followed by desquamation and exfoliation during ATRA therapy.
American Psychological Association (APA)
Ipek, Yonal& Hulya, Dogru& Melih, Aktan. 2012. Disseminated Exfoliative Dermatitis Associated with All-Transretinoic Acid in the Treatment of Acute Promyelocytic Leukemia. Case Reports in Medicine،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-456127
Modern Language Association (MLA)
Ipek, Yonal…[et al.]. Disseminated Exfoliative Dermatitis Associated with All-Transretinoic Acid in the Treatment of Acute Promyelocytic Leukemia. Case Reports in Medicine No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-456127
American Medical Association (AMA)
Ipek, Yonal& Hulya, Dogru& Melih, Aktan. Disseminated Exfoliative Dermatitis Associated with All-Transretinoic Acid in the Treatment of Acute Promyelocytic Leukemia. Case Reports in Medicine. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-456127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456127