Role of HOCO in the Control of Peripheral Circulation in Humans
Joint Authors
Sacerdoti, David
Mania, Despina
Gaiani, Silvia
Bolognesi, Massimo
Gatta, Angelo
Pesce, Paola
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-04
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Experimental studies show that the heme oxygenase/carbon monoxide system (HO/CO) plays an important role in the homeostasis of circulation and in the pathophysiology of hypertension.
No data are available on its role in the control of peripheral circulation in humans.
We evaluated the effects of inhibition of HO with stannous mesoporphyrin IX (SnMP) (200 μM) locally administered by iontophoresis, on human skin blood flow, evaluated by laser-Doppler flowmetry, in the presence and absence of nitric oxide synthase (NOS) inhibition with L-NG-Nitroarginine methyl ester (L-NAME) (100 μM).
We also evaluated the effect of HO inhibition on vasodilatation induced by acetylcholine (ACh) and vasoconstriction caused by noradrenaline (NA).
SnMP and L-NAME caused a similar 20–25% decrease in skin flow.
After nitric oxide (NO) inhibition with L-NAME, HO inhibition with SnMP caused a further 20% decrease in skin perfusion.
SnMP decreased vasodilatation induced by ACh by about 70%, while it did not affect vasoconstriction to NA.
In conclusion, HO/CO participates in the control of peripheral circulation, independently from NO, and is involved in vasodilatation to ACh.
American Psychological Association (APA)
Sacerdoti, David& Mania, Despina& Pesce, Paola& Gaiani, Silvia& Gatta, Angelo& Bolognesi, Massimo. 2012. Role of HOCO in the Control of Peripheral Circulation in Humans. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-456128
Modern Language Association (MLA)
Sacerdoti, David…[et al.]. Role of HOCO in the Control of Peripheral Circulation in Humans. International Journal of Hypertension No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-456128
American Medical Association (AMA)
Sacerdoti, David& Mania, Despina& Pesce, Paola& Gaiani, Silvia& Gatta, Angelo& Bolognesi, Massimo. Role of HOCO in the Control of Peripheral Circulation in Humans. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-456128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456128