CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson’s Disease
Joint Authors
Jayaraj, Richard L.
Singh, Sonu
Manigandan, Krishnan
Shukla, Shubha
Elangovan, Namasivayam
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Copious experimental and postmortem studies have shown that oxidative stress mediated degeneration of nigrostriatal dopaminergic neurons underlies Parkinson’s disease (PD) pathology.
CNB-001, a novel pyrazole derivative of curcumin, has recently been reported to possess various neuroprotective properties.
This study was designed to investigate the neuroprotective mechanism of CNB-001 in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) rodent model of PD.
Administration of MPTP (30 mg/kg for four consecutive days) exacerbated oxidative stress and motor impairment and reduced tyrosine hydroxylase (TH), dopamine transporter, and vesicular monoamine transporter 2 (VMAT2) expressions.
Moreover, MPTP induced ultrastructural changes such as distorted cristae and mitochondrial enlargement in substantia nigra and striatum region.
Pretreatment with CNB-001 (24 mg/kg) not only ameliorated behavioral anomalies but also synergistically enhanced monoamine transporter expressions and cosseted mitochondria by virtue of its antioxidant action.
These findings support the neuroprotective property of CNB-001 which may have strong therapeutic potential for treatment of PD.
American Psychological Association (APA)
Jayaraj, Richard L.& Elangovan, Namasivayam& Manigandan, Krishnan& Singh, Sonu& Shukla, Shubha. 2014. CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson’s Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-456129
Modern Language Association (MLA)
Jayaraj, Richard L.…[et al.]. CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson’s Disease. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-456129
American Medical Association (AMA)
Jayaraj, Richard L.& Elangovan, Namasivayam& Manigandan, Krishnan& Singh, Sonu& Shukla, Shubha. CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson’s Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-456129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456129