Amyloid Beta Peptide Slows Down Sensory-Induced Hippocampal Oscillations
Joint Authors
Peña-Ortega, Fernando
Bernal-Pedraza, Ramón
Source
International Journal of Peptides
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Alzheimer’s disease (AD) progresses with a deterioration of hippocampal function that is likely induced by amyloid beta (Aβ) oligomers.
Hippocampal function is strongly dependent on theta rhythm, and disruptions in this rhythm have been related to the reduction of cognitive performance in AD.
Accordingly, both AD patients and AD-transgenic mice show an increase in theta rhythm at rest but a reduction in cognitive-induced theta rhythm.
We have previously found that monomers of the short sequence of Aβ (peptide 25–35) reduce sensory-induced theta oscillations.
However, considering on the one hand that different Aβ sequences differentially affect hippocampal oscillations and on the other hand that Aβ oligomers seem to be responsible for the cognitive decline observed in AD, here we aimed to explore the effect of Aβ oligomers on sensory-induced theta rhythm.
Our results show that intracisternal injection of Aβ1–42 oligomers, which has no significant effect on spontaneous hippocampal activity, disrupts the induction of theta rhythm upon sensory stimulation.
Instead of increasing the power in the theta band, the hippocampus of Aβ-treated animals responds to sensory stimulation (tail pinch) with an increase in lower frequencies.
These findings demonstrate that Aβ alters induced theta rhythm, providing an in vivo model to test for therapeutic approaches to overcome Aβ-induced hippocampal and cognitive dysfunctions.
American Psychological Association (APA)
Peña-Ortega, Fernando& Bernal-Pedraza, Ramón. 2012. Amyloid Beta Peptide Slows Down Sensory-Induced Hippocampal Oscillations. International Journal of Peptides،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-456142
Modern Language Association (MLA)
Peña-Ortega, Fernando& Bernal-Pedraza, Ramón. Amyloid Beta Peptide Slows Down Sensory-Induced Hippocampal Oscillations. International Journal of Peptides No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-456142
American Medical Association (AMA)
Peña-Ortega, Fernando& Bernal-Pedraza, Ramón. Amyloid Beta Peptide Slows Down Sensory-Induced Hippocampal Oscillations. International Journal of Peptides. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-456142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456142