T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer
Joint Authors
Strauss, L.
Liao, T.
Kaufmann, A. M.
Hoffmann, Thomas
Albers, A. E.
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The competent immune system controls disease effectively due to induction, function, and regulation of effector lymphocytes.
Immunosurveillance is exerted mostly by cytotoxic T-lymphocytes (CTLs) while specific immune suppression is associated with tumor malignancy and progression.
In squamous cell carcinoma of the head and neck, the presence, activity, but also suppression of tumor-specific CTL have been demonstrated.
Functional CTL may exert a selection pressure on the tumor cells that consecutively escape by a combination of molecular and cellular evasion mechanisms.
Certain of these mechanisms target antitumor effector cells directly or indirectly by affecting cells that regulate CTL function.
This results in the dysfunction or apoptosis of lymphocytes and dysregulated lymphocyte homeostasis.
Another important tumor-escape mechanism is to avoid recognition by dysregulation of antigen processing and presentation.
Thus, both induction of functional CTL and susceptibility of the tumor and its microenvironment to become T cell targets should be considered in CTL-based immunotherapy.
American Psychological Association (APA)
Albers, A. E.& Strauss, L.& Liao, T.& Hoffmann, Thomas& Kaufmann, A. M.. 2010. T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-456154
Modern Language Association (MLA)
Albers, A. E.…[et al.]. T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer. Clinical and Developmental Immunology No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-456154
American Medical Association (AMA)
Albers, A. E.& Strauss, L.& Liao, T.& Hoffmann, Thomas& Kaufmann, A. M.. T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-456154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456154