Comparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development
Joint Authors
Bowick, Gavin C.
Barrett, Alan D. T.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Developing vaccines to biothreat agents presents a number of challenges for discovery, preclinical development, and licensure.
The need for high containment to work with live agents limits the amount and types of research that can be done using complete pathogens, and small markets reduce potential returns for industry.
However, a number of tools, from comparative pathogenesis of viral strains at the molecular level to novel computational approaches, are being used to understand the basis of viral attenuation and characterize protective immune responses.
As the amount of basic molecular knowledge grows, we will be able to take advantage of these tools not only to rationally attenuate virus strains for candidate vaccines, but also to assess immunogenicity and safety in silico.
This review discusses how a basic understanding of pathogenesis, allied with systems biology and machine learning methods, can impact biodefense vaccinology.
American Psychological Association (APA)
Bowick, Gavin C.& Barrett, Alan D. T.. 2010. Comparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-456167
Modern Language Association (MLA)
Bowick, Gavin C.& Barrett, Alan D. T.. Comparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-456167
American Medical Association (AMA)
Bowick, Gavin C.& Barrett, Alan D. T.. Comparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-456167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456167