PGC-1α Induction in Pulmonary Arterial Hypertension
Joint Authors
Ridocci, F.
Gil, Juan
Fabregat-Andrés, O.
Naufal, Dolores
Ramon, Mercedes
Cortijo, Julio
Sarrion, Irene
Juan, Gustavo
Mata, Manuel
Milian, Lara
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Idiopathic Pulmonary arterial hypertension (IPAH) is characterized by the obstructive remodelling of pulmonary arteries, and a progressive elevation in pulmonary arterial pressure (PAP) with subsequent right-sided heart failure and dead.
Hypoxia induces the expression of peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α) which regulates oxidative metabolism and mitochondrial biogenesis.
We have analysed the expression of PGC-1α, cytochrome C (CYTC), superoxide dismutase (SOD), the total antioxidant status (TAS) and the activity of glutathione peroxidase (GPX) in blood samples of IPAH patients.
Expression of PGC-1α was detected in IPAH patients but not in healthy volunteers.
The mRNA levels of SOD were lower in IPAH patients compared to controls (3.93 ± 0.89 fold change).
TAS and GPX activity were lower too in patients compared to healthy donors, (0.13 ± 0.027 versus 0.484 ± 0.048 mM and 56.034 ± 10.37 versus 165.46 ± 11.38 nmol/min/mL, resp.).
We found a negative correlation between expression levels of PGC-1α and age, PAP and PVR, as well as a positive correlation with CI, PaO2, mRNA levels of CYTC and SOD, TAS and GPX activity.
These results taken together are indicative of the possible role of PGC-1α as a potential biomarker of the progression of IPAH.
American Psychological Association (APA)
Mata, Manuel& Sarrion, Irene& Milian, Lara& Juan, Gustavo& Ramon, Mercedes& Naufal, Dolores…[et al.]. 2012. PGC-1α Induction in Pulmonary Arterial Hypertension. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-456173
Modern Language Association (MLA)
Mata, Manuel…[et al.]. PGC-1α Induction in Pulmonary Arterial Hypertension. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-456173
American Medical Association (AMA)
Mata, Manuel& Sarrion, Irene& Milian, Lara& Juan, Gustavo& Ramon, Mercedes& Naufal, Dolores…[et al.]. PGC-1α Induction in Pulmonary Arterial Hypertension. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-456173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456173