![](/images/graphics-bg.png)
Development of a New Tool for 3D Modeling for Regenerative Medicine
Joint Authors
Montesano, Simona
Orlacchio, Antonio
Martino, Sabata
Mattoli, Filippo
Crispoltoni, Lucia
Orlacchio, Aldo
D'Angelo, Francesco
di Girolamo, Ilaria
Cusella De Angelis, Maria Gabriella
Marconi, Peggy
Tiribuzi, Roberto
Quattrocelli, Mattia
Sampaolesi, Maurilio
Oikonomou, Vasileios
Source
International Journal of Biomedical Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The effectiveness of therapeutic treatment based on regenerative medicine for degenerative diseases (i.e., neurodegenerative or cardiac diseases) requires tools allowing the visualization and analysis of the three-dimensional (3D) distribution of target drugs within the tissue.
Here, we present a new computational procedure able to overcome the limitations of visual analysis emerging by the examination of a molecular signal within images of serial tissue/organ sections by using the conventional techniques.
Together with the 3D anatomical reconstitution of the tissue/organ, our framework allows the detection of signals of different origins (e.g., marked generic molecules, colorimetric, or fluorimetric substrates for enzymes; microRNA; recombinant protein).
Remarkably, the application does not require the employment of specific tracking reagents for the imaging analysis.
We report two different representative applications: the first shows the reconstruction of a 3D model of mouse brain with the analysis of the distribution of the β-Galactosidase, the second shows the reconstruction of a 3D mouse heart with the measurement of the cardiac volume.
American Psychological Association (APA)
Mattoli, Filippo& Tiribuzi, Roberto& D'Angelo, Francesco& di Girolamo, Ilaria& Quattrocelli, Mattia& Montesano, Simona…[et al.]. 2011. Development of a New Tool for 3D Modeling for Regenerative Medicine. International Journal of Biomedical Imaging،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-456195
Modern Language Association (MLA)
Mattoli, Filippo…[et al.]. Development of a New Tool for 3D Modeling for Regenerative Medicine. International Journal of Biomedical Imaging No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-456195
American Medical Association (AMA)
Mattoli, Filippo& Tiribuzi, Roberto& D'Angelo, Francesco& di Girolamo, Ilaria& Quattrocelli, Mattia& Montesano, Simona…[et al.]. Development of a New Tool for 3D Modeling for Regenerative Medicine. International Journal of Biomedical Imaging. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-456195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456195