Detection of Fastidious Vaginal Bacteria in Women with HIV Infection and Bacterial Vaginosis
Joint Authors
Fredricks, David N.
Cu-Uvin, Susan
Mitchell, Caroline M.
Ingersoll, Jessica
Kurpewski, Jaclynn
Moreira, Carla
Paul, Kathleen
Caliendo, Angela M.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Fastidious bacteria have been associated with bacterial vaginosis (BV) using PCR methods.
We assessed the prevalence of these bacteria in HIV-1 infected women and their relationship with vaginal pH and shedding of HIV-1 RNA.
Methods.
64 cervicovaginal lavage (CVL) samples were collected from 51 women.
Vaginal microbiota were characterized using 8 bacterium-specific quantitative PCR assays.
Results.
Women with the fastidious bacteria Bacterial Vaginosis Associated Bacterium (BVAB) 1, 2, and 3 showed a trend to increased HIV-1 shedding (OR 2.59–3.07, P=.14–.17).
Absence of Lactobacillus crispatus (P<.005) and presence of BVAB2 (P<.001) were associated with elevated vaginal pH.
BVAB1, 2, and 3 were highly specific indicators of BV in HIV-infected women, with specificities of 89%–93%.
Conclusions.
Fastidious bacteria (BVAB 1, 2, and 3) remain specific indicators of BV in HIV-infected women, and BVAB2 may contribute to the elevated vaginal pH that is a hallmark of this syndrome.
American Psychological Association (APA)
Mitchell, Caroline M.& Moreira, Carla& Fredricks, David N.& Paul, Kathleen& Caliendo, Angela M.& Kurpewski, Jaclynn…[et al.]. 2009. Detection of Fastidious Vaginal Bacteria in Women with HIV Infection and Bacterial Vaginosis. Infectious Diseases in Obstetrics and Gynecology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-456199
Modern Language Association (MLA)
Mitchell, Caroline M.…[et al.]. Detection of Fastidious Vaginal Bacteria in Women with HIV Infection and Bacterial Vaginosis. Infectious Diseases in Obstetrics and Gynecology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-456199
American Medical Association (AMA)
Mitchell, Caroline M.& Moreira, Carla& Fredricks, David N.& Paul, Kathleen& Caliendo, Angela M.& Kurpewski, Jaclynn…[et al.]. Detection of Fastidious Vaginal Bacteria in Women with HIV Infection and Bacterial Vaginosis. Infectious Diseases in Obstetrics and Gynecology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-456199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456199