Genetic Factors of Autoimmune Thyroid Diseases in Japanese
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Autoimmune thyroid diseases (AITDs), including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), are caused by immune response to self-thyroid antigens and affect approximately 2–5% of the general population.
Genetic susceptibility in combination with external factors, such as smoking, viral/bacterial infection, and chemicals, is believed to initiate the autoimmune response against thyroid antigens.
Abundant epidemiological data, including family and twin studies, point to a strong genetic influence on the development of AITDs.
Various techniques have been employed to identify genes contributing to the etiology of AITDs, including candidate gene analysis and whole genome screening.
These studies have enabled the identification of several loci (genetic regions) that are linked to AITDs, and, in some of these loci, putative AITD susceptibility genes have been identified.
Some of these genes/loci are unique to GD and HT and some are common to both diseases, indicating that there is a shared genetic susceptibility to GD and HT.
Known AITD-susceptibility genes are classified into three groups: HLA genes, non-HLA immune-regulatory genes (e.g., CTLA-4, PTPN22, and CD40), and thyroid-specific genes (e.g., TSHR and Tg).
In this paper, we will summarize the latest findings on AITD susceptibility genes in Japanese.
American Psychological Association (APA)
Ban, Yoshiyuki. 2011. Genetic Factors of Autoimmune Thyroid Diseases in Japanese. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-456206
Modern Language Association (MLA)
Ban, Yoshiyuki. Genetic Factors of Autoimmune Thyroid Diseases in Japanese. Autoimmune Diseases No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-456206
American Medical Association (AMA)
Ban, Yoshiyuki. Genetic Factors of Autoimmune Thyroid Diseases in Japanese. Autoimmune Diseases. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-456206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456206