Anti-Transglutaminase 6 Antibodies in Children and Young Adults with Cerebral Palsy
Joint Authors
Stenberg, Reidun
Hoggard, Nigel
Aeschlimann, Pascale
Hadjivassiliou, Marios
Aeschlimann, Daniel
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
We have previously reported a high prevalence of gluten-related serological markers (GRSM) in children and young adults with cerebral palsy (CP).
The majority had no enteropathy to suggest coeliac disease (CD).
Antibodies against transglutaminase 6 (anti-TG6) represent a new marker associated with gluten-related neurological dysfunction.
The aim of this study was to investigate the prevalence of anti-TG6 antibodies in this group of individuals with an early neurological injury resulting in CP.
Materials and Methods.
Sera from 96 patients with CP and 36 controls were analysed for IgA/IgG class anti-TG6 by ELISA.
Results.
Anti-TG6 antibodies were found in 12/96 (13%) of patients with CP compared to 2/36 (6%) in controls.
The tetraplegic subgroup of CP had a significantly higher prevalence of anti-TG6 antibodies 6/17 (35%) compared to the other subgroups and controls.
There was no correlation of anti-TG6 autoantibodies with seropositivity to food proteins including gliadin.
Conclusions.
An early brain insult and associated inflammation may predispose to future development of TG6 autoimmunity.
American Psychological Association (APA)
Stenberg, Reidun& Hadjivassiliou, Marios& Aeschlimann, Pascale& Hoggard, Nigel& Aeschlimann, Daniel. 2014. Anti-Transglutaminase 6 Antibodies in Children and Young Adults with Cerebral Palsy. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-456222
Modern Language Association (MLA)
Stenberg, Reidun…[et al.]. Anti-Transglutaminase 6 Antibodies in Children and Young Adults with Cerebral Palsy. Autoimmune Diseases No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-456222
American Medical Association (AMA)
Stenberg, Reidun& Hadjivassiliou, Marios& Aeschlimann, Pascale& Hoggard, Nigel& Aeschlimann, Daniel. Anti-Transglutaminase 6 Antibodies in Children and Young Adults with Cerebral Palsy. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-456222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456222