Nicotine Enemas for Active Crohn's Colitis : An Open Pilot Study
Joint Authors
Ingram, J. R.
Rhodes, J.
Evans, B. K.
Thomas, G. A. O.
Source
Gastroenterology Research and Practice
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-03-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Smoking has a detrimental effect in Crohn's disease (CD), but this may be due to factors in smoking other than nicotine.
Given that transdermal nicotine benefits ulcerative colitis (UC), and there is a considerable overlap in the treatment of UC and CD, the possible beneficial effect of nicotine has been examined in patients with Crohn's colitis.
Aims.
To assess the efficacy and safety of nicotine enemas in active Crohn's colitis.
Patients.
Thirteen patients with active rectosigmoid CD; 3 patients were excluded because they received antibiotics.
Methods.
Subjects were given 6 mg nicotine enemas, each day for 4 weeks, in an open pilot study.
At the beginning and end of the trial, a Crohn's disease activity index (CDAI) score was calculated, sigmoidoscopy was performed, and haematological inflammatory markers measured.
Results.
Mean CDAI decreased from 202 to 153—the score was reduced in 6 patients, unchanged in 3, and increased in one.
Frequency of bowel movements decreased in 8 patients and the sigmoidoscopy grade was reduced in 7.
Mean C-reactive protein decreased from 22.0 to 12.3 mg/L.
There were no withdrawals due to adverse events.
Conclusions.
In this relatively small study of patients with active Crohn's colitis, 6 mg nicotine enemas appeared to be of clinical benefit in most patients.
They were well tolerated and safe.
American Psychological Association (APA)
Ingram, J. R.& Rhodes, J.& Evans, B. K.& Thomas, G. A. O.. 2008. Nicotine Enemas for Active Crohn's Colitis : An Open Pilot Study. Gastroenterology Research and Practice،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-456227
Modern Language Association (MLA)
Ingram, J. R.…[et al.]. Nicotine Enemas for Active Crohn's Colitis : An Open Pilot Study. Gastroenterology Research and Practice No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-456227
American Medical Association (AMA)
Ingram, J. R.& Rhodes, J.& Evans, B. K.& Thomas, G. A. O.. Nicotine Enemas for Active Crohn's Colitis : An Open Pilot Study. Gastroenterology Research and Practice. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-456227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456227