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Association between AgNORs and Immunohistochemical Expression of ER, PR, HER2neu, and p53 in Breast Carcinoma
Joint Authors
Ahmed, Hussain Gad ElKarim
al-Adhraei, Mohammed Ali
Ashankyty, Ibraheem M.
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Settings.
Despite the limited diagnostic utility of AgNORs (argyrophilic nucleolar organiser region-associated proteins) for individual breast lesions, AgNOR analysis bears a significant potential for characterizing cell proliferative activity of breast lesions.
Methodology.
The present study investigated the relationship between mean AgNORs count and immunohistochemical expression of ER, PR, HER2/neu, and p53 in breast carcinoma in serial paraffin sections from 137 breast carcinomas.
Twenty control cases of benign breast lesions were included.
Results.
Mean AgNOR counts correlated significantly inversely with hormone estrogen receptors (ER), Progesterone receptors (PR), and p53 immunohistochemical expression, denoting P values of 0.05, 0.01, and 0.001, respectively.
No significant correlation was found between mean AgNOR counts and HER2/neu, P=0.9.
Mean AgNOR count was significantly higher in grade II tumor cells.
We conclude that mean AgNOR counts correlate with ER, PR, and P53 tumor markers in breast carcinomas.
Conclusion.
We recommend the use of mean AgNOR count for accurate reporting of breast carcinomas, as well as prediction of ER, PR, and P53 in routine paraffin sections.
American Psychological Association (APA)
Ahmed, Hussain Gad ElKarim& al-Adhraei, Mohammed Ali& Ashankyty, Ibraheem M.. 2011. Association between AgNORs and Immunohistochemical Expression of ER, PR, HER2neu, and p53 in Breast Carcinoma. Pathology Research International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-456229
Modern Language Association (MLA)
Ahmed, Hussain Gad ElKarim…[et al.]. Association between AgNORs and Immunohistochemical Expression of ER, PR, HER2neu, and p53 in Breast Carcinoma. Pathology Research International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-456229
American Medical Association (AMA)
Ahmed, Hussain Gad ElKarim& al-Adhraei, Mohammed Ali& Ashankyty, Ibraheem M.. Association between AgNORs and Immunohistochemical Expression of ER, PR, HER2neu, and p53 in Breast Carcinoma. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-456229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456229