Simple Spectrophotometric Method for Determination of Paroxetine in Tablets Using 1,2-Naphthoquinone-4-Sulphonate as a Chromogenic Reagent
Joint Authors
Darwish, Ibrahim A.
Abdine, Heba H.
al-Rayes, Lama I.
Amer, Sawsan M.
Source
International Journal of Analytical Chemistry
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Simple and rapid spectrophotometric method has been developed and validated for the determination of paroxetine (PRX) in tablets.
The proposed method was based on nucleophilic substitution reaction of PRX with 1,2-naphthoquinone-4-sulphonate (NQS) in an alkaline medium to form an orange-colored product of maximum absorption peak (λmax) at 488 nm.
The stoichiometry and kinetics of the reaction were studied, and the reaction mechanism was postulated.
Under the optimized reaction conditions, Beer's law correlating the absorbance (A) with PRX concentration (C) was obeyed in the range of 1–8 μg mL−1.
The regression equation for the calibration data was: A = 0.0031 + 0.1609 C, with good correlation coefficients (0.9992).
The molar absorptivity (ε) was 5.9×105 L mol−1 1 cm−1.
The limits of detection and quantitation were 0.3 and 0.8 μg mL−1, respectively.
The precision of the method was satisfactory; the values of relative standard deviations did not exceed 2%.
The proposed method was successfully applied to the determination of PRX in its pharmaceutical tablets with good accuracy and precisions; the label claim percentage was 97.17±1.06 %.
The results obtained by the proposed method were comparable with those obtained by the official method.
American Psychological Association (APA)
Darwish, Ibrahim A.& Abdine, Heba H.& Amer, Sawsan M.& al-Rayes, Lama I.. 2009. Simple Spectrophotometric Method for Determination of Paroxetine in Tablets Using 1,2-Naphthoquinone-4-Sulphonate as a Chromogenic Reagent. International Journal of Analytical Chemistry،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-456263
Modern Language Association (MLA)
Darwish, Ibrahim A.…[et al.]. Simple Spectrophotometric Method for Determination of Paroxetine in Tablets Using 1,2-Naphthoquinone-4-Sulphonate as a Chromogenic Reagent. International Journal of Analytical Chemistry No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-456263
American Medical Association (AMA)
Darwish, Ibrahim A.& Abdine, Heba H.& Amer, Sawsan M.& al-Rayes, Lama I.. Simple Spectrophotometric Method for Determination of Paroxetine in Tablets Using 1,2-Naphthoquinone-4-Sulphonate as a Chromogenic Reagent. International Journal of Analytical Chemistry. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-456263
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456263