Serum Amyloid Alpha in Parapneumonic Effusions
Joint Authors
Boultadakis, Vagelis
Nikoulis, Dimitrios J.
Gourgoulianis, K. I.
Skouras, Vasilis
Damianaki, Aggeliki
Kiropoulos, Theodoros
Makris, Demosthenes
Tsilioni, Irene
Oikonomidi, Smaragda
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Study objectives.
To assess serum amyloid alpha (SAA) pleural fluid levels in parapneumonic effusion (PPE) and to investigate SAA diagnostic performance in PPE diagnosis and outcome.
Methods.
We studied prospectively 57 consecutive patients with PPE (empyema (EMP), complicated (CPE), and uncomplicated parapneumonic effusion (UPE)).
SAA, CRP, TNF-α, IL-1β, and IL-6 levels were evaluated in serum and pleural fluid at baseline.
Patients were followed for 6-months to detect pleural thickening/loculations.
Results.
Pleural SAA levels (mg/dL) median(IQR) were significantly higher in CPE compared to UPE (P<0.04); CRP levels were higher in EMP and CPE compared to UPE (P<0.01).
There was no significant difference between IL-1β, IL-6, TNF-α level in different PPE forms.
No significant association between SAA levels and 6-month outcome was found.
At 6-months, patients with no evidence of loculations/thickening had significantly higher pleural fluid pH, glucose levels (P=0.03), lower LDH (P=0.005), IL-1β levels (P=0.001) compared to patients who presented pleural loculations/thickening.
Conclusions.
SAA is increased in complicated PPE, and it might be useful as a biomarker for UPE and CPE diagnosis.
SAA levels did not demonstrate considerable diagnostic performance in identifying patients who develop pleural thickening/loculations after a PPE.
American Psychological Association (APA)
Boultadakis, Vagelis& Skouras, Vasilis& Makris, Demosthenes& Damianaki, Aggeliki& Nikoulis, Dimitrios J.& Kiropoulos, Theodoros…[et al.]. 2011. Serum Amyloid Alpha in Parapneumonic Effusions. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-456268
Modern Language Association (MLA)
Boultadakis, Vagelis…[et al.]. Serum Amyloid Alpha in Parapneumonic Effusions. Mediators of Inflammation No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-456268
American Medical Association (AMA)
Boultadakis, Vagelis& Skouras, Vasilis& Makris, Demosthenes& Damianaki, Aggeliki& Nikoulis, Dimitrios J.& Kiropoulos, Theodoros…[et al.]. Serum Amyloid Alpha in Parapneumonic Effusions. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-456268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456268