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Analysis of LAM and 38 kDa Antibody Levels for Diagnosis of TB in a Case-Control Study in West Africa
Joint Authors
Sutherland, Jayne S.
Donkor, Simon
Ota, Martin O. C.
Adetifa, Ifedayo M. O.
Gomez, Marie P.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
CD4+ T cells are required for protection against tuberculosis (TB) disease progression, but interest in the role of antibodies in early protection, as biomarkers for disease status, and use in diagnostic tests has recently increased.
In this study we analyzed plasma antibody levels in TB cases before and after treatment in both HIV-positive and -negative individuals and compared them with tuberculin skin test (TST+) (latently infected) household contacts (HHC).
We also analyzed HHC that subsequently progressed to active disease within 2 years in order to see if antibodies play a role in protection against disease progression.
We used a commercially available kit to 38 kDa antigen and lipoarabinomannan (LAM) and found that immunoglobulin (Ig) G levels were 4-fold higher in subjects with disease compared to latently infected controls (P<0.001) and were 2-fold higher than pretreatment levels following successful TB treatment (P<0.001 compared to both pretreated cases and latently infected controls).
HIV infection resulted in low antibody levels regardless of disease status or treatment outcome.
Furthermore, levels in disease progressors (incident cases) were similar to nonprogressors and were not elevated until just prior to disease progression confirming previous reports that IgG antibodies, at least in the periphery, do not confer protection against TB disease progression.
American Psychological Association (APA)
Gomez, Marie P.& Donkor, Simon& Adetifa, Ifedayo M. O.& Ota, Martin O. C.& Sutherland, Jayne S.. 2012. Analysis of LAM and 38 kDa Antibody Levels for Diagnosis of TB in a Case-Control Study in West Africa. ISRN Immunology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-456278
Modern Language Association (MLA)
Gomez, Marie P.…[et al.]. Analysis of LAM and 38 kDa Antibody Levels for Diagnosis of TB in a Case-Control Study in West Africa. ISRN Immunology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-456278
American Medical Association (AMA)
Gomez, Marie P.& Donkor, Simon& Adetifa, Ifedayo M. O.& Ota, Martin O. C.& Sutherland, Jayne S.. Analysis of LAM and 38 kDa Antibody Levels for Diagnosis of TB in a Case-Control Study in West Africa. ISRN Immunology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-456278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456278