Combination with Methotrexate and Cyclophosphamide Attenuated Maturation of Dendritic Cells : Inducing Treg Skewing and Th17 Suppression In Vivo
Joint Authors
Li, Xiaofeng
Wang, Caihong
Yu, Xiaoyang
Luo, Jing
Wang, Lixing
Zhao, Xiangcong
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Immune disorder is considered the main pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA).
The balance of the two special subsets of CD4+T cells, T helper cell 17 (Th17), and Regulator T cell (Treg) is the key factor of maintaining a normal immune response.
Dendritic cells (DCs), which are the most powerful antigen-presenting cells, play an important role in regulating the balance of Th17 and Treg.
The combination of disease modifying antirheumatic drugs (DMARDs) is an important strategy of RA therapy.
In this study, we investigated the effect of MTX and CTX on DC maturation in ovalbumin (OVA) immunized mice.
Th17 inflammatory response is stronger, while the level of DCs maturity is higher.
In contrast, the immunosuppression of Treg is stronger.
We found that MTX combined with CTX significantly inhibited the DCs maturity and downregulated the antigen presenting capacity of DCs.
As a result, it reestablished a balance of Th17 and Treg.
Our study adds a novel mechanism and therapeutic target of MTX combined with CTX for autoimmune disease treatment.
American Psychological Association (APA)
Yu, Xiaoyang& Wang, Caihong& Luo, Jing& Zhao, Xiangcong& Wang, Lixing& Li, Xiaofeng. 2013. Combination with Methotrexate and Cyclophosphamide Attenuated Maturation of Dendritic Cells : Inducing Treg Skewing and Th17 Suppression In Vivo. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-456301
Modern Language Association (MLA)
Yu, Xiaoyang…[et al.]. Combination with Methotrexate and Cyclophosphamide Attenuated Maturation of Dendritic Cells : Inducing Treg Skewing and Th17 Suppression In Vivo. Clinical and Developmental Immunology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-456301
American Medical Association (AMA)
Yu, Xiaoyang& Wang, Caihong& Luo, Jing& Zhao, Xiangcong& Wang, Lixing& Li, Xiaofeng. Combination with Methotrexate and Cyclophosphamide Attenuated Maturation of Dendritic Cells : Inducing Treg Skewing and Th17 Suppression In Vivo. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-456301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456301