The Serum Glycome to Discriminate between Early-Stage Epithelial Ovarian Cancer and Benign Ovarian Diseases

Joint Authors

Blanchard, Véronique
Tauber, Rudolf
Braicu, Elena Iona
Biskup, Karina
Sehouli, Jalid

Source

Disease Markers

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-08-12

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases

Abstract EN

Epithelial ovarian cancer (EOC) is the sixth most common cause of cancer deaths in women because the diagnosis occurs mostly when the disease is in its late-stage.

Current diagnostic methods of EOC show only a moderate sensitivity, especially at an early-stage of the disease; hence, novel biomarkers are needed to improve the diagnosis.

We recently reported that serum glycome modifications observed in late-stage EOC patients by MALDI-TOF-MS could be combined as a glycan score named GLYCOV that was calculated from the relative areas of the 11 N-glycan structures that were significantly modulated.

Here, we evaluated the ability of GLYCOV to recognize early-stage EOC in a cohort of 73 individuals comprised of 20 early-stage primary serous EOC, 20 benign ovarian diseases (BOD), and 33 age-matched healthy controls.

GLYCOV was able to recognize stage I EOC whereas CA125 values were statistically significant only for stage II EOC patients.

In addition, GLYCOV was more sensitive and specific compared to CA125 in distinguishing early-stage EOC from BOD patients, which is of high relevance to clinicians as it is difficult for them to diagnose malignancy prior to operation.

American Psychological Association (APA)

Biskup, Karina& Braicu, Elena Iona& Sehouli, Jalid& Tauber, Rudolf& Blanchard, Véronique. 2014. The Serum Glycome to Discriminate between Early-Stage Epithelial Ovarian Cancer and Benign Ovarian Diseases. Disease Markers،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-456313

Modern Language Association (MLA)

Biskup, Karina…[et al.]. The Serum Glycome to Discriminate between Early-Stage Epithelial Ovarian Cancer and Benign Ovarian Diseases. Disease Markers No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-456313

American Medical Association (AMA)

Biskup, Karina& Braicu, Elena Iona& Sehouli, Jalid& Tauber, Rudolf& Blanchard, Véronique. The Serum Glycome to Discriminate between Early-Stage Epithelial Ovarian Cancer and Benign Ovarian Diseases. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-456313

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-456313