![](/images/graphics-bg.png)
Gingyo-San Enhances Immunity and Potentiates Infectious Bursal Disease Vaccination
Joint Authors
Chong, Kowit-Yu
Kao, Shung-Te
Chen, Hsiao-Ling
Yen, Chih-Ching
Hung, Che-Ming
Yeh, Chia-Chou
Yeh, Ming-Hsien
Chen, Jiun-Yu
Chen, Chuan-Mu
Lin, Maw-Sun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The purpose of the present study was to investigate the effects of Gingyo-san (GGS), a traditional Chinese medical formula, on peripheral lymphocyte proliferation and serum antibody titers in chickens vaccinated against the infectious bursal disease (IBD) virus.
Treatment groups were fed one of three doses of GGS in their diet (0.5%, 1.0% and 2.0%, w/w), and the IBD vaccine was administered at 1 and 3 weeks of age.
At Weeks 8, 12 and 16, changes in serum IBD antibody titers were measured via the micro-method and T cell proliferation.
In gene expression experiments, GGS-treated peripheral T lymphocytes were stimulated with concanavalin A (ConA) for 24 h.
The mRNA expression of interleukin-2 (IL-2), interferon-γ (IFN-γ), interleukin-4 (IL-4) and interleukin-12 (IL-12) was determined using a semi-quantitative RT-PCR assay.
The results showed that a low dose of GGS could significantly raise the antibody titers.
Medium and high doses of GGS enhanced IL-2 and IFN-γ production.
GGS altered the expression of IL-4 and IL-12 in T lymphocytes.
CD4+ T lymphocyte development was also skewed towards the Th1 phenotype.
GGS enhanced cell-mediated immunity and augmented the effects of IBD vaccination in strengthening subsequent anti-viral responses.
American Psychological Association (APA)
Hung, Che-Ming& Yeh, Chia-Chou& Chong, Kowit-Yu& Chen, Hsiao-Ling& Chen, Jiun-Yu& Kao, Shung-Te…[et al.]. 2010. Gingyo-San Enhances Immunity and Potentiates Infectious Bursal Disease Vaccination. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-456315
Modern Language Association (MLA)
Hung, Che-Ming…[et al.]. Gingyo-San Enhances Immunity and Potentiates Infectious Bursal Disease Vaccination. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-456315
American Medical Association (AMA)
Hung, Che-Ming& Yeh, Chia-Chou& Chong, Kowit-Yu& Chen, Hsiao-Ling& Chen, Jiun-Yu& Kao, Shung-Te…[et al.]. Gingyo-San Enhances Immunity and Potentiates Infectious Bursal Disease Vaccination. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-456315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456315