Role of Methylglyoxal in Alzheimer’s Disease
Joint Authors
Angeloni, Cristina
Hrelia, Silvana
Zambonin, Laura
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Alzheimer’s disease is the most common and lethal neurodegenerative disorder.
The major hallmarks of Alzheimer’s disease are extracellular aggregation of amyloid β peptides and, the presence of intracellular neurofibrillary tangles formed by precipitation/aggregation of hyperphosphorylated tau protein.
The etiology of Alzheimer’s disease is multifactorial and a full understanding of its pathogenesis remains elusive.
Some years ago, it has been suggested that glycation may contribute to both extensive protein cross-linking and oxidative stress in Alzheimer’s disease.
Glycation is an endogenous process that leads to the production of a class of compounds known as advanced glycation end products (AGEs).
Interestingly, increased levels of AGEs have been observed in brains of Alzheimer’s disease patients.
Methylglyoxal, a reactive intermediate of cellular metabolism, is the most potent precursor of AGEs and is strictly correlated with an increase of oxidative stress in Alzheimer’s disease.
Many studies are showing that methylglyoxal and methylglyoxal-derived AGEs play a key role in the etiopathogenesis of Alzheimer's disease.
American Psychological Association (APA)
Angeloni, Cristina& Zambonin, Laura& Hrelia, Silvana. 2014. Role of Methylglyoxal in Alzheimer’s Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-456346
Modern Language Association (MLA)
Angeloni, Cristina…[et al.]. Role of Methylglyoxal in Alzheimer’s Disease. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-456346
American Medical Association (AMA)
Angeloni, Cristina& Zambonin, Laura& Hrelia, Silvana. Role of Methylglyoxal in Alzheimer’s Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-456346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456346