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Effects of SR141716A on Cognitive and Depression-Related Behavior in an Animal Model of Premotor Parkinson's Disease
Joint Authors
Da Cunha, C.
Tadaiesky, M. T.
Dombrowski, P. A.
Takahashi, R. N.
Source
International Journal of Mathematics and Mathematical Sciences
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A previous study from our laboratory revealed that moderate nigral dopaminergic degeneration caused emotional and cognitive deficits in rats, paralleling early signs of Parkinson's disease.
Recent evidence suggests that the blockade of cannabinoid CB1 receptors might be beneficial to alleviate motor inhibition typical of Parkinson's disease.
Here, we investigated whether antagonism of CB1 receptors would improve emotional and cognitive deficits in a rat model of premotor Parkinson's disease.
Depression-like behavior and cognition were assessed with the forced swim test and the social recognition test, respectively.
Confirming our previous study, rats injected with 6-hydroxydopamine in striatum presented emotional and cognitive alterations which were improved by acute injection of SR141716A.
HPLC analysis of monoamine levels demonstrated alterations in the striatum and prefrontal cortex after SR141716A injection.
These findings suggest a role for CB1 receptors in the early symptoms caused by degeneration of dopaminergic neurons in the striatum, as observed in Parkinson's disease.
American Psychological Association (APA)
Tadaiesky, M. T.& Dombrowski, P. A.& Da Cunha, C.& Takahashi, R. N.. 2010. Effects of SR141716A on Cognitive and Depression-Related Behavior in an Animal Model of Premotor Parkinson's Disease. International Journal of Mathematics and Mathematical Sciences،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-456349
Modern Language Association (MLA)
Tadaiesky, M. T.…[et al.]. Effects of SR141716A on Cognitive and Depression-Related Behavior in an Animal Model of Premotor Parkinson's Disease. International Journal of Mathematics and Mathematical Sciences No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-456349
American Medical Association (AMA)
Tadaiesky, M. T.& Dombrowski, P. A.& Da Cunha, C.& Takahashi, R. N.. Effects of SR141716A on Cognitive and Depression-Related Behavior in an Animal Model of Premotor Parkinson's Disease. International Journal of Mathematics and Mathematical Sciences. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-456349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456349