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Allergic Potential and Immunotoxicity Induced by Topical Application of 1-Chloro-4-(Trifluoromethyl)Benzene (PCBTF) in a Murine Model
Joint Authors
Jackson, Laurel G.
Meade, B. Jean
Franko, Jennifer
Anderson, Stacey E.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The purpose of the studies in this paper was to evaluate the allergic potential, immunotoxicity, and irritancy of the occupationally relevant chemical, 1-chloro-4-(trifluoromethyl)benzene, also known as parachlorobenzotrifluoride (PCBTF), following dermal exposure in a murine model.
Evaluation of the sensitization potential, conducted using the local lymph node assay (LLNA) at concentrations ranging from 50% to 100%, identified a dose-dependent increase in lymphocyte proliferation with a calculated EC3 value of 53.1%.
While no elevations in total or specific IgE were observed after exposure to any concentration of the chemical, significant increases in IFN-γ protein production by stimulated draining lymphoid cells were observed, indicating a T-cell-mediated response.
Dermal exposure to PCBTF was not found to alter the immune response to a T-cell-dependant antigen.
These results demonstrate that PCBTF has the potential to induce allergic sensitization following dermal exposure and based on LLNA results would be classified as a weak sensitizer.
American Psychological Association (APA)
Franko, Jennifer& Jackson, Laurel G.& Meade, B. Jean& Anderson, Stacey E.. 2011. Allergic Potential and Immunotoxicity Induced by Topical Application of 1-Chloro-4-(Trifluoromethyl)Benzene (PCBTF) in a Murine Model. Journal of Allergy،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-456352
Modern Language Association (MLA)
Franko, Jennifer…[et al.]. Allergic Potential and Immunotoxicity Induced by Topical Application of 1-Chloro-4-(Trifluoromethyl)Benzene (PCBTF) in a Murine Model. Journal of Allergy No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-456352
American Medical Association (AMA)
Franko, Jennifer& Jackson, Laurel G.& Meade, B. Jean& Anderson, Stacey E.. Allergic Potential and Immunotoxicity Induced by Topical Application of 1-Chloro-4-(Trifluoromethyl)Benzene (PCBTF) in a Murine Model. Journal of Allergy. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-456352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456352