Contact Heterogeneity and Phylodynamics : How Contact Networks Shape Parasite Evolutionary Trees
Joint Authors
O'Dea, Eamon B.
Wilke, Claus O.
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The inference of population dynamics from molecular sequence data is becoming an important new method for the surveillance of infectious diseases.
Here, we examine how heterogeneity in contact shapes the genealogies of parasitic agents.
Using extensive simulations, we find that contact heterogeneity can have a strong effect on how the structure of genealogies reflects epidemiologically relevant quantities such as the proportion of a population that is infected.
Comparing the simulations to BEAST reconstructions, we also find that contact heterogeneity can increase the number of sequence isolates required to estimate these quantities over the course of an epidemic.
Our results suggest that data about contact-network structure will be required in addition to sequence data for accurate estimation of a parasitic agent's genealogy.
We conclude that network models will be important for progress in this area.
American Psychological Association (APA)
O'Dea, Eamon B.& Wilke, Claus O.. 2010. Contact Heterogeneity and Phylodynamics : How Contact Networks Shape Parasite Evolutionary Trees. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-456387
Modern Language Association (MLA)
O'Dea, Eamon B.& Wilke, Claus O.. Contact Heterogeneity and Phylodynamics : How Contact Networks Shape Parasite Evolutionary Trees. Interdisciplinary Perspectives on Infectious Diseases No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-456387
American Medical Association (AMA)
O'Dea, Eamon B.& Wilke, Claus O.. Contact Heterogeneity and Phylodynamics : How Contact Networks Shape Parasite Evolutionary Trees. Interdisciplinary Perspectives on Infectious Diseases. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-456387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456387