Autologous Stem Cell Transplant for AL Amyloidosis
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
AL amyloidosis is caused by clonal plasma cells that produce immunoglobulin light chains which misfold and get deposited as amyloid fibrils.
Therapy directed against the plasma cell clone leads to clinical benefit.
Melphalan and corticosteroids have been the mainstay of treatment for a number of years and the recent availability of other effective agents (IMiDs and proteasome inhibitors) has increased treatment options.
Autologous stem cell transplant (ASCT) has been used in the treatment of AL amyloidosis for many years.
It is associated with high rates of hematologic response and improvement in organ function.
However, transplant carries considerable risks.
Careful patient selection is important to minimize transplant related morbidity and mortality and ensure optimal patient outcomes.
As newer more affective therapies become available the role and timing of ASCT in the overall treatment strategy of AL amyloidosis will need to be continually reassessed.
American Psychological Association (APA)
Roy, Vivek. 2012. Autologous Stem Cell Transplant for AL Amyloidosis. Bone Marrow Research،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-456401
Modern Language Association (MLA)
Roy, Vivek. Autologous Stem Cell Transplant for AL Amyloidosis. Bone Marrow Research No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-456401
American Medical Association (AMA)
Roy, Vivek. Autologous Stem Cell Transplant for AL Amyloidosis. Bone Marrow Research. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-456401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456401