![](/images/graphics-bg.png)
The Role of Endoplasmic Reticulum Stress in Autoimmune-Mediated Beta-Cell Destruction in Type 1 Diabetes
Joint Authors
Zhong, Jixin
Rao, Xiaoquan
Yang, Ping
Wang, Cong-Yi
Xu, Jun-Fa
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Unlike type 2 diabetes which is caused by the loss of insulin sensitivity, type 1 diabetes (T1D) is manifested by the absolute deficiency of insulin secretion due to the loss of β mass by autoimmune response against β-cell self-antigens.
Although significant advancement has been made in understanding the pathoetiology for type 1 diabetes, the exact mechanisms underlying autoimmune-mediated β-cell destruction, however, are yet to be fully addressed.
Accumulated evidence demonstrates that endoplasmic reticulum (ER) stress plays an essential role in autoimmune-mediated β-cell destruction.
There is also evidence supporting that ER stress regulates the functionality of immune cells relevant to autoimmune progression during T1D development.
In this paper, we intend to address the role of ER stress in autoimmune-mediated β-cell destruction during the course of type 1 diabetes.
The potential implication of ER stress in modulating autoimmune response will be also discussed.
We will further dissect the possible pathways implicated in the induction of ER stress and summarize the potential mechanisms underlying ER stress for mediation of β-cell destruction.
A better understanding of the role for ER stress in T1D pathoetiology would have great potential aimed at developing effective therapeutic approaches for the prevention/intervention of this devastating disorder.
American Psychological Association (APA)
Zhong, Jixin& Rao, Xiaoquan& Xu, Jun-Fa& Yang, Ping& Wang, Cong-Yi. 2012. The Role of Endoplasmic Reticulum Stress in Autoimmune-Mediated Beta-Cell Destruction in Type 1 Diabetes. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-456402
Modern Language Association (MLA)
Zhong, Jixin…[et al.]. The Role of Endoplasmic Reticulum Stress in Autoimmune-Mediated Beta-Cell Destruction in Type 1 Diabetes. Experimental Diabetes Research No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-456402
American Medical Association (AMA)
Zhong, Jixin& Rao, Xiaoquan& Xu, Jun-Fa& Yang, Ping& Wang, Cong-Yi. The Role of Endoplasmic Reticulum Stress in Autoimmune-Mediated Beta-Cell Destruction in Type 1 Diabetes. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-456402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456402